Half-Day Hands-on Course

The first part of the training course will be led by Assoc. Prof. DI Dr. Heidrun Gruber-Woelfler of Graz University of Technology and will be looking at the theory of synthesis in Flow and to an introduction to work-up, crystallisation and filtration processes.

The second part of the training course will be led by Dr Thomas McGlone Technical Operations Manager at CMAC National Facility.

Attendees will have at their disposal 6 different stations with 6 different DEMOS (several flow chemistry reactions, crystallization, formulation) and will gain insights of an end to end continuous process.

2-3 stations will focus on different synthesis reactions.

A model compound will be run through 4 stages – synthesis, work-up, crystallisation and filtration. These will be linked into a continuous, ‘end-to-end process’. This will give delegates the opportunity to observe some downstream operations (following synthesis).

A separate station will demonstrate hot melt extrusion (HME) and how the output of this can be linked with 3-D printing, moving towards applications in personalised medicine.

Assoc.Prof. Heidrun Gruber-Woelfler
Graz University of Technology

Hands-on course Instructor

 

Assoc.Prof. Heidrun Gruber-Woelfler studied technical chemistry at Graz University of Technology, Austria with a focus on chemical engineering. After her PhD dealing with organometallic catalysis, she did her Post-Doc in the area of continuous processes for the synthesis and purification of active pharmaceutical ingredients and finished her habilitation (venia docendi) in the field of Pharmaceutical Engineering in 2018.

Since 2007 she is the head of the research group “Continuous Processes” at the Institute of Process and Particle Engineering, Graz University of Technology and since July 2017 Deputy Director of the Center of Continuous Flow Synthesis and Processing (CCFlow) in Graz. Her current projects deal with heterogeneous (bio)catalysis for API synthesis, continuous processes, reactor design including additive manufacturing as well as in-line analyses.

Dr Thomas McGlone
Technical Operations Manager – CMAC

Technical Operations Manager – CMAC

Chemistry MSci Graduate from the University of Glasgow. He also completed his PhD at Glasgow under the supervision of Professor Lee Cronin within the area of inorganic synthesis, crystallisation and characterisation. Thomas joined CMAC in 2011 as a knowledge exchange postdoctoral researcher, working with Fujifilm and Syngenta. He then worked with the CMAC Tier 1 companies, GSK, Novartis and Astrazeneca on the Exquisite particles project. All of these projects investigated the feasibility of moving from batch to continuous crystallisation including practical aspects such as fouling. Thomas then joined the core Phase II CMAC centre programme, working to develop a workflow for the design of a continuous crystallisation process. An additional interest is process analytical technology and how this can be applied to monitor crystallisation processes.

Thomas is now the Technical Operations Manager for the CMAC National Facility and is responsible for managing the instrument scientists and research technician team, health and safety, and overseeing CMAC’s multi-million pound asset base.