POSTERS

CECILIA BOTTECCHIA
Senior Scientist at Merck

Poster: Photochemistry in flow as an enabling and scalable tool

Biography:
Cecilia Bottecchia was born in Milan, Italy in 1989. In 2014, she received her M.Sc. degree in Chemistry and Pharmaceutical Technologies at the University of Milan. Previously, she conducted her master thesis under the supervision of Prof. A. Madder at Ghent University, Belgium. After her undergraduate studies, Cecilia joined the group of Dr. Timothy Noël at the Eindhoven University of Technology in the Netherlands, working on biomolecule functionalization via photocatalysis in continuous‐flow.In2019, she obtained her PhD title cum laudeand then joined the flow team at Merck, Rahway (NJ, USA) where she continues to develop continuous flow methods for process chemistry.

DENIS LYNCH
University College Cork

Poster: Real-time Monitoring of Diazo Transfer Processes by FlowNMR

Biography:
Denis Lynch is from Co. Cork, he completed both his B.Sc. and Ph.D. in Chemistry at UCC. After working for GSK in 2014, as part of its Technical Shared Services team based in Cork, he returned to UCC to a post-doctoral research position with Prof. Anita Maguire, engaged on a collaborative project with a pharmaceutical company. Since 2015, he has been working as part of the Synthesis and Solid State Pharmaceutical Centre (SSPC) on research in continuous flow processing, directed by Prof. Anita Maguire and Dr. Stuart Collins at UCC; this work has focused on advanced process control, including the use of PAT, and on developing safe approaches to hazardous synthetic transformations through flow chemistry, particularly with respect to diazo chemistry and diazo transfer processes. His other research interests include transition-metal catalysis, asymmetric synthesis, total synthesis and NMR spectroscopy.

ELIZE SMIT
University of Johannesburg

Poster: Development of a 3D-printed countercurrent separation device for continuous flow systems

Biography:
Dr Elize Smit is a lecturer of Chemistry at the University of Johannesburg, South Africa. She obtained her PhD in 2016 under supervision of Prof Egmont Rohwer (University of Pretoria) and Dr Stefan de Goede (Sasol). Her postgraduate research focussed on the development of chromatography, high resolution mass spectrometry and other techniques for the analysis of petrochemical samples to better understand their physical properties. Her current research is focussed on the analysis of complex mixtures, e.g. those obtained from multi-substrate screening of catalysts, and the use of combinatorial methods to streamline catalyst synthesis and evaluation. She is also interested in the incorporation of technology in both research and teaching, e.g. open source electronics and 3D-printing.

JASON D. WILLIAMS
Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria
Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

Poster: Applications of Flow Photochemistry towards Industrial Scale Processing

Biography:
Jason Williams is a Postdoctoral Researcher under Prof. C. Oliver Kappe at Research Center Pharmaceutical Engineering GmbH (RCPE), based in Graz (Austria). He completed his undergraduate degree in Chemistry at the University of Sheffield (UK), pursuing a masters project in the group of Prof. Iain Coldham, studying lithiation of saturated nitrogen heterocycles. This was later followed by a PhD on the GlaxoSmithKline/University of Strathclyde collaborative PhD Programme, based in the process chemistry group at GSK Stevenage, working on novel amidation methods using organometallic chemistry in flow and photoredox chemistry. In April 2018, Jason took up a postdoctoral position within CC FLOW (part of RCPE). His current research interests are focused in the areas of flow photochemistry and PAT/process control in flow.

JOSE CAPDEVILA-ECHEVERRIA
– Collaborative International Research Programme: University of Strathclyde (Glasgow), Nanyang Technological University (Singapore), and The Hong Kong University of Science and Technology (Hong Kong)
– University of Strathclyde, EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallization (CMAC), Strathclyde Institute of Pharmacy and Biomedical Sciences, Technology and Innovation Centre, 99 George Street, Glasgow G1 1RD, United Kingdom

Poster:  Process Modelling and Optimisation of Continuous Chiral Resolution by Integration of Membrane and Crystallisation Technologies

Biography:
Jose Capdevila-Echeverria was born in Lleida (Spain). He completed his BSc in Chemistry in University of Barcelona, MSci in Pharmaceutical Chemistry at Chemical Institute of Sarrià (Barcelona), and has an MBA from Open University of Catalonia. He showed academic interests related to materials science, organic chemistry, chemical engineering, data science, project management, and business administration.

He was trained in a combination of academic and industrial research and business skills from his experiences in Max Planck Institute for Polymer Research (Germany), Institute of Chemical Research of Catalonia (Spain), Institute for Advanced Chemistry of Catalonia from the Spanish National Research Council (Spain), Ferrer HealthTech (Spain), CaixaBank (Spain), The Hong Kong University of Science and Technology (Hong Kong, China), and CMAC Future Manufacturing Research Hub (United Kingdom).

He is currently pursuing his PhD in Chemical Engineering in CMAC Future Manufacturing Research Hub (University of Strathclyde), under the supervision of Prof. Joop H. ter Horst. His PhD project is an international collaboration among CMAC Future Manufacturing Research Hub (United Kingdom), Nanyang Technological University (Singapore), and The Hong Kong University of Science and Technology (Hong Kong, China). It aims at combining and integrating membrane and crystallisation technologies to develop continuous chiral resolution processes.

KOICHIRO MASUDA
Interdisciplinary Research Center for Catalytic Chemistry, National Institute of Advanced Industrial Science and Technology (AIST)

Poster: Immobilized Rose Bengal as a Highly Active and Durable Heterogeneous Sensitizer for Continuous-flow Photooxidative Reactions

Biography:
Koichiro Masuda received B.Sc. in chemistry and M.Sc. in chemistry from the University of Tokyo, Japan, in 2010 and 2012, respectively. I then received my Ph. D. in Science in 2015 under supervision of Prof. Dr. Shu Kobayashi in the same institute. During Ph. D., I developed a new quantitative technique to analyze heterogeneous reaction mixture in real time by using mass spectrometry. I was working as a postdoctoral research fellow in the University of Tokyo and currently am in National Institute of Advanced Industrial Science and Technology (AIST) from this April. My current interests are continuous flow technique as a novel synthetic methodology for the facile preparation of complex molecules, and immobilized photocatalysts and acid/base catalysts for C-C bond forming reactions.

NOEL QUIGLEY
Managing Director BPE Design and Support Ltd

Poster: Continuous Reactor Modelling – Selecting the right solution

Biography:
A chartered engineer and Fellow of IChemE with vast experience of senior management and project leadership, Noel joined BPE as technology director before being appointed as managing director in 2018. Having held senior process engineering roles with Procter & Gamble and GlaxoSmithKline, he truly understands client’s challenges and needs. Noel has considerable experience of developing new concepts through to commercial solutions, complimented by project leadership and functional management roles within both client and contractor organisations. This unique combination of inhouse and management experience makes him a vital resource for BPE’s clients. Noel has published papers on a number of technology areas including filtration scale up and continuous reactor modelling.

REINOUT VAN KERREBROECK
SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Gent, Belgium

Poster: Circumventing the use of molecular bromine by performing electrophilic bromination reactions in continuous flow

Biography:
Reinout Van Kerrebroeck (1994) obtained his master’s degree in Bioscience Engineering, Chemistry and Bioprocess Technology in 2016 at Ghent University. He then started working on a PhD in the SynBioC research group under the guidance of Prof. Christian V. Stevens (SynBioC, Faculty of Bioscience Engineering). His PhD focusses on improving the safety and sustainability of halogenation reactions by performing them in continuous flow, but he is also involved in several other projects, mostly also concerning continuous flow.

ADAM CLARKE
AstraZeneca

Poster: Understanding Micromixing – Scale up of mixing sensitive reactions at AstraZeneca

Biography:
Adam obtained a master’s in chemical engineering from the University of Bath, UK. During his degree Adam spent a year working as a pilot plant engineer at Pfizer.

For last 3 years Adam has been working as a process engineer in the Chemical Development function of AstraZeneca. Most of his work in the continuous area has been focussed on developing in-house capability to quantify micromixing performance of reactors for scale-up of mixing sensitive reactions. He is now broadening his skillset to cover modelling and scale-up of reaction and work-up. Adam has an active interest in characterisation of reactor and work-up equipment, the implementation of predictive modelling and de-risking of scale-up activities in flow.