Timothy F. Jamison
Professor of Chemistry, Massachusetts Institute of Technology, Department of Chemistry

Tim Jamisonwas born in San Jose, CA and grew up in neighboring Los Gatos, CA. He received his undergraduate education at the University of California, Berkeley. A six-month research assistantship at ICI Americas in Richmond, CA under the mentorship of Dr. William G. Haag was his first experience in chemistry research. Upon returning to Berkeley, he joined the laboratory of Prof. Henry Rapoport and conducted undergraduate research in his group for nearly three years, the majority of which was under the tutelage of William D. Lubell (now at the University of Montreal). A Fulbright Scholarship supported ten months of research in Prof. Steven A. Benner’s laboratories at the ETH in Zürich, Switzerland, and thereafter he undertook his PhD studies at Harvard University with Prof. Stuart L. Schreiber. He then moved to the laboratory of Prof. Eric N. Jacobsen at Harvard University, where he was a Damon Runyon-Walter Winchell postdoctoral fellow. In July 1999, he began his independent career at MIT, where his research program focuses on the development of new methods of organic synthesis and their implementation in the total synthesis of natural products.

Lecture: On-Demand Synthesis?

Timothy Noël
Eindhoven University of Technology
Chairman & Keynote Speaker

Timothy Noël 
received in 2004 his MSc degree (Industrial Chemical Engineering) from the KaHo Sint-Lieven in Ghent. He then moved to Ghent University to obtain a PhD at the Laboratory for Organic and Bioorganic Synthesis (2005-2009). Next, he moved to Massachusetts Institute of Technology (MIT) as a Fulbright Postdoctoral Fellow with Professor Stephen L. Buchwald. At MIT, he worked at the MIT-Novartis Center for Continuous Manufacturing. He currently holds a position as an associate professor in the Micro Flow Chemistry & Process Technology group at Eindhoven University of Technology. His research interests are flow chemistry, homogeneous and heterogeneous catalysis and organic synthesis.

Lecture: “Innovation in synthetic methodology through use of flow”

Craig Johnston
Industry Director – CMAC
Panel discussion moderator

Craig Johnston is Industry Director at (CMAC) Continuous Manufacturing and Advanced Crystallisation. Established in 2011, CMAC is a world-class international centre for manufacturing research and training. Working in partnership with industry it is transforming medicines development and manufacture. Craig works with Tier 1 industry members (GSK, AZ, Novartis, Bayer, Pfizer, Takeda, Eli Lilly, Roche and Pfizer) and a range of technology companies. Craig is a Fellow of the Institute of Chemical Engineers and has a MBA. His previous industrial career spanned 22 years, working for ICI, Zeneca, Avecia and Fujifilm. Responsibilities included plant management, new product introduction, process improvement, capital expenditure and process technology leadership. He is co-founder and COO of sustainable protein business 3F BIO Ltd.

Nick Thomson
Senior Director, Chemical Research and Development, Pfizer Inc.

Nick graduated from the University of Edinburgh with a BSc (Hons) in Environmental Chemistry before completing a PhD in organic synthesis under Prof. Gerry Pattenden at the University of Nottingham. Nick worked briefly at Zeneca Fine Chemicals Manufacturing Organization, Grangemouth (UK) and joined Pfizer in 1997 as a synthetic chemist in Process Research & Development. Nick spent his early Pfizer career in the evolving process chemistry departments in Sandwich (UK), Sittingbourne (UK) and Holland, Michigan (USA). From 2005 to 2010, Nick led the Sandwich Research Active Pharmaceutical Ingredient (API) department, with accountability for delivery of API technology from lead development to proof of concept. In 2011, Nick joined the Pfizer Chemical Research and Development department in Groton, Connecticut (USA), as a Director of API Process Chemistry Laboratories, with accountability for the Quality by Design development and submission of late stage candidates. In 2014, Nick became head of the Technology API line for Pfizer Chemical Research and Development, with accountability for Technology Strategy, High Throughput Screening, Biocatalysis and Flexible API Supply Technologies (Continuous). Nick has been active in cross pharmaceutical precompetitive collaboration, as Chair of the IQ API Leadership Team and a board member of the Enabling Technologies Consortium.

Nick and his wife Jill have two children, Ben (fifteen) and Anna (thirteen) and live in East Lyme, Connecticut, close to the beach. In his spare time, Nick enjoys oil painting. He coaches youth soccer and is a South Eastern Connecticut Junior Soccer Association trained youth coach and referee. Nick is a board member for the East Lyme Soccer Association and is the Girls Coordinator, accountable for delivery of the girl’s youth soccer program in East Lyme.

Lecture: “Flexible API Supply Technologies (FAST); Continuous Technologies for Greater Agility in API Development and Manufacturing”

Heidrun Gruber-Woelfler
Graz University of Technology
Hands-on course Instructor


Assoc.Prof. Heidrun Gruber-Woelfler studied technical chemistry at Graz University of Technology, Austria with a focus on chemical engineering. After her PhD dealing with organometallic catalysis, she did her Post-Doc in the area of continuous processes for the synthesis and purification of active pharmaceutical ingredients and finished her habilitation (venia docendi) in the field of Pharmaceutical Engineering in 2018.

Since 2007 she is the head of the research group “Continuous Processes” at the Institute of Process and Particle Engineering, Graz University of Technology and since July 2017 Deputy Director of the Center of Continuous Flow Synthesis and Processing (CCFlow) in Graz. Her current projects deal with heterogeneous (bio)catalysis for API synthesis, continuous processes, reactor design including additive manufacturing as well as in-line analyses.

Thomas McGlone
Technical Operations Manager – CMAC


Chemistry MSci Graduate from the University of Glasgow. He also completed his PhD at Glasgow under the supervision of Professor Lee Cronin within the area of inorganic synthesis, crystallisation and characterisation. Thomas joined CMAC in 2011 as a knowledge exchange postdoctoral researcher, working with Fujifilm and Syngenta. He then worked with the CMAC Tier 1 companies, GSK, Novartis and Astrazeneca on the Exquisite particles project. All of these projects investigated the feasibility of moving from batch to continuous crystallisation including practical aspects such as fouling. Thomas then joined the core Phase II CMAC centre programme, working to develop a workflow for the design of a continuous crystallisation process. An additional interest is process analytical technology and how this can be applied to monitor crystallisation processes.

Thomas is now the Technical Operations Manager for the CMAC National Facility and is responsible for managing the instrument scientists and research technician team, health and safety, and overseeing CMAC’s multi-million pound asset base.

Xiongwei Ni
Chief Science Director – NiTech Solutions Ltd


Professor Xiongwei Ni was involved in the development of oscillatory flow technology at its inception in 1988 at the University of Cambridge, UK. He has over 20 years’ research experience and the world expert in the science and technological applications of oscillatory baffled reactors (OBR).

Xiongwei obtained his first degree in Chongqing University, China in 1982, his PhD degree in Leeds University, UK in 1986. He was then a postdoc at Edinburgh and Cambridge Universities, UK. Xiongwei has been a Full Professor in Chemical Engineering at Heriot-Watt University, Edinburgh since August 1999, is the lead author or principal co-author of over 230 scientific papers on OBR related research as well as 8 patents. He was the keynote speaker at American Institute of Chemical Engineering Annual Meetings, Process Intensification Conferences, Scientific Update Conferences, Industrial Seminars of Process Engineering, Society of Chemical Industry Symposium and the Royal Society of Chemistry Symposiums. He delivered over 160 invited seminars at Universities and industries in the USA, France, Germany, the Netherlands, Belgium, Spain, Portugal, Finland, Sweden, Norway, Denmark, Hungary, Israel, UK, Ireland, Canada, Australia, New Zealand, China and Japan.

In 2001, Xiongwei was elected as a Fellow of Institute of Chemical Engineers (FIChemE) and in 2014 a Fellow of the Royal Society of Chemistry (FRSC). Xiongwei has been one of the two UK representatives in Process Intensification in the European Federation of Chemical Engineering since 2005.

In 2005 Xiongwei span off a company, NiTech Solutions Ltd, which specializes continuous reactions and crystallization, has directly involved in a large number of synthesis and crystallization of APIs, fine chemicals and food products, and has gained significant insights into these types of operation. He serves the role of chief science director.

Lecture: Continuous hydrogenation of 3-Butyn-2-ol over Pd/Al2O3 in a Continuous Oscillatory Baffled Reactor

Matthew M. Bio
President & CEO, Snapdragon Chemistry, Inc.


Dr. Matthew Bio is President & CEO at Snapdragon Chemistry. Matthew began his career in chemistry more than 20 years ago developing continuous processes for the manufacture and purification of acrylates at the former Rohm & Haas company.  Matthew then moved to Columbia University and earned a PhD in Chemistry.  Upon graduating, Matthew returned to industry as a process development chemist at Merck Research Laboratories.  In 2006 Matthew moved to Amgen where he was Director of Process Development.  At Amgen, Matthew led the development of both batch and continuous processes for clinical candidates and drove innovation in technologies for the manufacture of synthetic – biologic hybrid molecules.  In 2015, Matthew joined Snapdragon Chemistry, Inc., a contract development firm specialized in the design of continuous manufacturing technology.  Throughout his career, Matthew has been involved in the development of more than 50 clinical candidates and the launch of three new drugs to the market.  He is author or inventor on more than 30 peer reviewed publications and patents and numerous regulatory filings.  Matthew is driven by a passion for the development of new technologies in organic synthesis to enable safer, more efficient processes and providing access to new chemical architectures.

Lecture: Mighty Machines; Rapid and robust scaling of drug substance processes in purpose-built reactors enabled by continuous manufacturing technology

Anne O’Kearney-McMullan

Anne is the Associate Principal Chemist for Continuous Processing at AstraZeneca. Her background is in chemistry having obtained a BSc from University College Cork in Ireland.  She’s worked in both Research and Process Development within AstraZeneca and for the last ten years has been leading both the development and manufacture of several AstraZeneca drug product intermediates using continuous processing.

Lecture: How Continuous Processing is making a difference at AstraZeneca

Flavien Susanne

Flavien Susanne
completed his M.S.E in 2001 and Chemical Engineering Degree in 2003 from the University on Normandy, France. Flavien has held several roles with increasing responsibility in development of continuous processing at Pfizer, Novartis and GlaxoSmithKline and is currently the R&D lead for Continuous Drug Substance Processing at GlaxoSmithKline. Within his role, Flavien is accountable of the development and implementation of single stage and multistage flow processes from R&D facilities to GMP manufacturing site.

Flavien is leading the interactions between GlaxoSmithKline and various consortium such as CMAC and PIPs or precompetitive collaboration with other pharmaceutical companies for continuous application.

Lecture to be defined

Frederic Buono
Senior Principal Scientist
Chemical Development- Boehringer-Ingelheim

Dr. Frederic Buono has 15 years of experience in Pharmaceutical Industry and he is working for past 7 years in Boehringer Ingelheim (USA-Ridgefield, CT) as Senior Principal Scientist, where he is leading continuous process group. Dr. Frederic Buono is originally from France, where he got his PhD in organic chemistry and chemical engineer degree from “Ecole Centrale de Marseille”. He did his postdoctoral research under supervision of Pr. D. Blackmond (UK-Hull), where he works in the area of physical organic chemistry and he developed several kinetic models of organic reaction mechanisms. He started his career with Bristol Myers Squibb (NJ) in Process Group, and particularly in a Technology group. In his current position at Boehringer Ingelheim, he is leading, developing and implementing continuous flow technology for several projects from gram to multi-kilogram scale process, by using in-situ monitoring techniques, kinetic studies and modeling for process optimization. Frederic is author of many publications and book chapters in the field of mechanistic studies and continuous processing.

Lecture: Breaking Barriers To Manufacturing Innovation with Continuous Flow Technology

Edgar Steffin
Head of Marketing
De Dietrich Process Systems GmbH in Mainz, Germany

Edgar Steffin has spent one year of his studies at the University of Bordeaux and received in 1990 his MSc in chemical engineering from the Technical University of Darmstadt upon simulated reaction kinetics. He then completed in 1995 his PhD at the same University in Germany with the focus on the reaction rates of a hydrogenation in a CFR. Having worked briefly at a company manufacturing mini plant systems he joined in 1997 QVF now De Dietrich Process Systems GmbH in Mainz. In the beginning he was implementing the business with systems for research and process development in Asia and North America. From 2001 he was responsible for the sales of mini and pilot scale systems as well as production plants in Scandinavia and Eastern Europe including Russia. Since 2012 until now Edgar Steffin has been handling the marketing activities and hence conveying the technological solutions for the chemical and pharmaceutical industry.

Lecture: Cryogenic flow chemistry made easy: the skid concept

Raf Reintjens
Principal scientist process intensification
InnoSyn B.V.

Raf Reintjens
graduated in 1984 as a chemical engineer at the Technical University of Eindhoven. He started his career at DSM in process development of fine chemicals derived from hydrocyanic acid. As project manager for business development he was responsible for outsourcing pre-marketing production of newly developed processes to toll-manufacturing service providers. Leading a process development group, he gained experience in scaling-up and pilot plant operation. Experience with bulk chemical operation and large capital projects followed at the DSM toluene oxidation plant in Rotterdam. During this period, significant investments were made to improve the profitability of the site, which meant working closely with engineering, equipment manufacturers and contractors. From this bulk chemical production environment, he switched to competence management for Process Intensification. In that role he was responsible for the identification of promising PI technologies, the expertise development and roll out in business applications. During that period, he experienced what it took to bridge the gap between TRL3 and TRL7. His team introduced 3D metal printing as the game changing manufacturing technology for industrial micro reactors. In May 2017, when InnoSyn was formed, he left DSM to join InnoSyn. Since then he is the Principal Scientist of InnoSyn on Process Intensification in general and the company expert on specifically the industrialization of flow chemistry.

Lecture: Cryogenic flow chemistry made easy: the skid concept

Guillaume Gauron
EMEA Technical Sales ManagerReactor Technologies
Corning SAS

Dr. Guillaume Gauron obtained his Ph.D. in Organic Chemistry from “Université d’Orsay Paris XI” in 2007. He started his industrial career at IBA Molecular (Cis Bio) as a R&D radiochemist.

During his seven years at IBA Molecular, he had the opportunity to work in all phases of the development cycle of aseptic radiopharmaceutical products. From development, qualification, validation, clinical trials, to final-stage technology transfer to production teams in Europe and US.

In 2014, he joined Corning as an Application Engineer for the Advanced Flow Reactors business where he managed client projects from early stage technical interactions through to the installation phase of customer projects. Beginning in 2018, Dr. Gauron assumed leadership of technical sales for Corning’s Advanced Flow Reactor business in the EMEA region.

Lecture: Flow chemistry panorama and API scale up stories

Mikaël Paugam
Section Head
Oril Industrie

Dr. Mikaël Paugamobtained his PhD in organic chemistry at INSA Rouen/IRCOF in Professor QUEGUINER laboratory, under de supervision of A. GODARD and F. MARSAIS, in 2001. He worked on the selectivity improvement of metalation reaction by molecular interaction.

Then in 2002 he join ISOCHEM as head of process chemistry laboratory. From 2003 to 2005, Mikaël worked in HIV Domain (NNRTI inhibitors)as a research assistant for JANSSEN-CILAG. He went back to ISOCHEM as Head of the process chemistry laboratory as well as Process safety Manager for nine years.

Since 2014 he is leading multipurpose team (Process safety assessment, Crystallization process development, Continuous Process development) at ORIL Industrie – SERVIER.

Lecture: Flow chemistry panorama and API scale up stories

Charlotte Wiles
Chemtrix BV

Starting her research in the area of continuous flow synthesis in 2000, Charlotte obtained her PhD in 2003 entitled ‘Microreactors in organic synthesis’. This was followed by 5 years of postdoctoral research into the rapidly developing field of continuous flow synthesis, specifically in the area of heterogeneous catalysis for small molecule synthesis.

In 2008, Charlotte joined Chemtrix BV as a Senior Chemist where she worked on the commercialisation of lab-scale micro reactor apparatus & in 2010 she was promoted to Chief Technology Officer within Chemtrix BV continuing to develop & characterise pilot-scale flow reactors. In 2013 she became CEO of Chemtrix BV, where she continues to research and develop continuous flow systems and solutions for Partners, with more recent developments focussing on the implementation of flow reactors in Industry for multi-metric tonne-scale manufacturing. These activities build on the scalable reactor platform developed in cooperation with 3M Technical Ceramics.

Lecture: Commercialisation of Process Intensification – Bridging the Chemist & Engineer Divide!

Wouter Stam

After his Master degree in Chemical Engineering he worked for major oil & chemical multinationals and industrial service companies.
In 2004 Wouter started working for a leading biotech company on process development and controlled release.
Going from batch to flow showed to be a challenge and Wouter saw the business and technology opportunity, being process intensification in flow.
He founded Flowid in 2008 to focus solely on flow solutions for production, pilot and lab scale. Key is a fully integrated setup with the right pumps, controls, process computer and for sure the right reactors for the specific customer demands.
Flowid developed a special line of flow reactors with excellent mass and heat transfer. Flowid’s SpinPro reactors are excellent solutions for the most demanding multiphase (G/L, L/L) exothermic reactions and have fully integrated utility.
Flowid’s knowhow and technology makes precipitation and emulsification processes easy to perform and to control.
Prerequisite for Flowid is scalability from lab, pilot to production and vice versa.

Lecture: Commercialisation of Process Intensification – Bridging the Chemist & Engineer Divide!

Darren Whitaker
Senior Engineering Consultant
Perceptive Engineering Limited

Darren has a PhD in Analytical Chemistry and Spectroscopy from the University of Bradford. Following this he went on to carry out Postdoctoral research at the Institute of technology, Sligo and the University of Limerick focussing on process analytical technology and process control. He has recently taken up the post of a senior application consultation with Perceptive Engineering working on advanced process control technology.

Lecture: Machine Learning for Rapid Pharmaceutical Process Development

Guido Furlotti
RR&D- Synthetic Product & Process Laboratories Manager

I took the degree in chemistry “cum laude” at the University of Rome “La Sapienza”, Italy in 1996 with professor M.A. Loreto with an experimental thesis in organic chemistry focused on the study of the reactivity of allenyl silanes with nitrenes.
In 1998, I joined the multinational pharmaceutical company based in Italy Angelini S.p.A as synthetic chemist in the R&D center in Santa Palomba (Rome, IT). After three year (2001), mainly involved in drug discovery programs as bench chemist, I took the newly established position of Head of Combinatorial Chemistry Lab. In this position I managed the creation and the development of this new laboratory as well as the deep involvement of the unit in the company’s hit-to-lead and lead optimization programs.
From 2011 to 2016, head of Medicinal Chemistry, managing the design, synthesis, and “stage & gate” progression of biological active compounds in different therapeutic areas (CNS, anti-infective, ophthalmology, inflammation).
From 2016 to present, Synthetic Product and Process laboratory, focusing the department activity to support Angelini’s API manufacturing plant with process research & development and trouble-shooting programs. In this period, we have directed our attention to the innovative approaches of the drug substance manufacture, such as the flow chemistry.
In more than 20 years of experience in the pharmaceutical industry I authored about 30 publications, between patent applications and scientific articles, as well as several presentations in scientific events.

Lecture: Continuous Manufacturing Process: the new approach for an old API